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Orally administered, Emothion® is clinically effective in increasing GSH in humans

DESIO, Italy - August 16th, 2018

The clinical efficacy and pharmacokinetic profile of Emothion® - the S-Acetyl Glutathione (SAG) produced by Gnosis - have been evaluated in a human randomised, open-label, two-sequence, two-period, cross-over bioavailability study, versus a qualified reference product of glutathione (GSH).

The above study, published by a scientific group of the Sapienza University of Rome (Fanelli et al., Int J Clin Nutr Diet 2018), revealed a significant difference between Emothion® and the reference formulations both in terms of Cmax and AUC0-t of GSH in erythrocytes. 

The study has a relevant significance because it is the first one testing the impact of the administration of the S-Acetyl Glutathione as a prodrug (Emothion®) on GSH levels in plasma and erythrocytes in humans.

SAG was not quantifiable in any plasma sample. This result shows that deacetylation of SAG occurs rapidly after its administration and that the whole amount of the substance is transformed into GSH before reaching the blood stream.

About Emothion® - S-Acetyl Glutathione

EMOTHION® is the crystalline form of S-Acetyl Glutathione, with a rapid dissolution rate and therefore it is orally well absorbed.
S-Acetyl Glutathione is more stable than GSH itself in plasma and is taken up directly by cells and later converted to GSH.
The acetylation of the sulfur atom prevents the decomposition of GSH and facilitates its absorption through the intestinal wall as is, thus enabling the molecule to pass extensively into the cells. Moreover, cysteinyl acetylation prevents the oxidation of the thiol group before its absorption. After absorption, SAG is hydrolyzed by cytoplasmic thioesterases [8-9], so releasing a GSH pool available for the cells.

EMOTHION® is a precursor of glutathione and works as a GSH-replenishment agent.

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